Feng-Zhi Shi^a, Yin-Dong Fang^b,c, Min Fan^a, Xian-Jun Jiang^b,c, Shuang Wang^a,*, Guo-Zhu Wei^b,c,**

^a College of Pharmacy, Dili University, Dali 671000, People's Republic of China

^b BioBioPha Co., Ltd., Kunming 650201, People's Republic of China

^c Reference Substance Branch, National Engineering Research Center for Modernization of Traditional Chinese Medicine, Kunming 650201, People's Republic of China

Abstract

Six new compounds, including two depsidones garciculendepsidones A and B (1 and 2), one prenylated xanthone garciculenxanthone (3) and three dimeric xanthones bigarciculenxanthones A–C (4–6), were isolated from the twigs and leaves of Garcinia esculenta Y. H. Li. Their structures were elucidated based on comprehensive analyses of spectral data, including HRESIMS, 1D and 2D NMR, and ECD calculation. All the isolates were tested for their cytotoxicity against fve human cancer cell lines (myeloid leukemia HL-60, lung cancer A-549 cells, hepatocellular carcinoma SMMC-7721, breast cancer MDA-MB-231 and colon cancer SW480), among them, compounds 3–5 displayed cytotoxic potential, especially garciculenxanthone (3) had the lowest IC50 value of 8.2 μm for lung cancer A-549 cells.

文章链接：https://doi.org/10.1016/j.fitote.2023.105779